HHV-1 = predominantly oral - HHV-2 = predominantly genital

Type	Synonym	Subfamily	Primary Target Cell	Pathophysiology	Site of Latency	Means of Spread
HHV-1	Herpes simplex virus-1 (HSV-1)	α (Alpha)	Mucoepithelial	Oral and/or genital herpes (predominantly orofacial), as well as other herpes simplex infections	Neuron	Close contact
HHV-2	Herpes simplex virus-2 (HSV-2)	α	Mucoepithelial	Oral and/or genital herpes (predominantly genital), as well as other herpes simplex infections	Neuron	Close contact (sexually transmitted disease)

There are eight distinct viruses in this family known to cause disease in humans

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